Embryo implantation failure is part of what we called the dreaded diagnosis of unexplained infertility where people are putting out so much time, effort, money, emotion and yet it keeps repeating with each IVF cycles.
For unexplained failure of implantation we would say that it is usually two cycles of really good embryos that are transferred, with proper number of embryos, easy transfer, the cycle looking great but the outcome is either not getting pregnant or even worse those early slowly rising HCG levels where everybody knows it’s just a matter of time until it ends in a miscarriage. At RHG, we try to give her a chance of having nausea, vomiting, breast tenderness, and a 20-30% chance of caesarean section because we believe she is going to make a good incubator if we can select the best investigation and treatment approach.
The treatments we offer help us tailor her next treatment cycle closely to her needs. Around one-third of implantation failure cases are due to embryo abnormalities. And we know sometimes an embryo can be perfect and still can’t implant due to her womb lining. Our extensive recurrent implantation tests help us look into the embryo factors, paternal factors, endometrial tests, and maternal factors. Briefly they assess the mother’s clotting profile, immune screening, levels of uterine natural killer cells and autoantibodies. Hysteroscopy is a test which allows us to assess the womb cavity by direct viewing and carry out treatments if required. High levels of sperm DNA fragmentation have been linked with miscarriage and treatment options such as testicular sperm extraction for ICSI can benefit those couples. Preimplantation genetic testing helps us select the best euploid embryo while time lapse imaging of the embryo (The GERI™ timelapse system) monitors embryo cell divisions and these cell time points help predict further development potential. Overall, they allow us to select the best embryo which will be more likely to implant.