The integrity of genetic material in the sperm is crucial for successful fertilisation and normal embryo development. Sperm DNA fragmentation is a term used to denote abnormal genetic material within the sperm, which in turn may lead to male subfertility, IVF failure and miscarriage. A conventional semen analysis done for sperm concentration, motility analysis and morphology assessment cannot assess the sperm at the molecular level and as result aid the detection of DNA fragmentation.
A number of sperm DNA fragmentation tests are available on the market, but the one used at the Reproductive Health Group, is the SpermComet test which seems to more detailed information compared to the other tests such as SCSA and TUNEL.
Studies in the literature have shown that:
- High sperm DNA fragmentation affects blastocyst development
- Higher the DNA fragmentation levels, higher the chances of failed assisted conception treatment and miscarriage
- Sperm DNA fragmentation is higher in subfertile men with abnormal sperm parameters
- Men with normal sperm parameters are also found to have high sperm DNA fragmentation